Does hyaluronidase injected in periocular area change skin ultrastructure?: Standardized in vitro analysis.

BACKGROUND: Treatment with hyaluronic acid (HA) fillers as a strategy for rejuvenation has experienced a significant growth in recent years, accompanied by a parallel increase in its complications, the treatment of which, such as hyaluronidase, we must be aware of. PATIENTS/METHODS: 14 patients (28 eyes) had indication for upper blepharoplasty surgery in the Hospital Universitario y Politécnico La Fe. After surgery, periocular skin of one eye of each patient was infiltrated with 300 U of hyaluronidase (14 cases) while the skin of the fellow eye was preserved untreated (14 controls). All samples were studied by the Pathology department, and finally, 6 variables (skin structure alteration, degeneration of elastic fibers, deposits, collagen fibers destructuring, inflammation, and other findings) were analyzed. RESULTS: No differences in skin structure, elastic fibers, and collagen dermal fibers were found between hyaluronidase-treated skin and controls. A significant association between ex vivo application of hyaluronidase in periocular skin and the presence of amorphous extracellular deposits within the dermis was found. CONCLUSIONS: Hyaluronidase applied ex vivo to periocular skin led to presence of deposits within the extracellular matrix compared to control eyelid skin but elastin and collagen dermis structure remained unaltered.

Leiomioma del pezón en un varón: presentación de un caso / Leiomyoma of the nipple in a male: A case report

El leiomioma del pezón es un tumor benigno y poco frecuente originado a partir de las fibras de músculo liso del tejido subareolar de la mama. Presentamos el caso de un varón con un leiomioma en el complejo areola-pezón izquierdo, destacando las características clínicas e histológicas de estos tumores, así como su manejo

Leiomyoma of the nipple is a rare benign tumour that is thought to arise from smooth muscle fibres in the subareolar tissue of the breast. We report the case of a male patient with a leiomyoma arising from his left nipple-areola complex. The clinical characteristics, gross and microscopic pathologic findings, and management of this lesion are discussed

[Mesonephroid adenocarcinoma. Apropos of a new case and review of the literature]. / Adenocarcinoma mesonefroide. A propósito de un nuevo caso y revisión de la literatura.

OBJECTIVES: Mesonephric adenocarcinoma is a rare clinical entity, predominantly appearing in women, involved in great controversy about its histogenesis. Reported cases to date were not diagnosed in their initial stages and they were treated by radical surgery with poor results. METHODS: We report the case of a 71-year-old male with previous diagnosis of nephrogenic adenoma two years before. RESULTS: After the diagnosis of mesonephric adenocarcinoma was established, patient underwent radical surgery despite its poor prognosis. CONCLUSIONS: Differential diagnosis between these tumors should be made with primary or metastatic adenocarcinoma and nephrogenic adenoma. We highlight the ongoing controversy in the literature in relation to malignant evolution of the nephrogenic adenoma as etiology of the rare mesonephric adenocarcinoma. In this case, previous finding of a nephrogenic adenoma would support that theory.

Adenocarcinoma mesonefroide. A propósito de un nuevo caso y revisión de la literatura / Mesonephric adenocarcinoma. Report of a new case and bibliographic review

OBJETIVOS: El adenocarcinoma mesonefroide es una entidad clínicas rara, con predominio en mujeres y con una gran controversia en cuanto a su histogénesis. Los casos recogidos hasta la actualidad no fueron diagnosticados en estadíos iniciales y tratados mediante cirugía radical con pobres resultados. MÉTODOS: Presentamos el caso de un varón de 71 años, con el diagnóstico previo dos años antes de adenoma nefrogénico, RESULTADOS: Tras ser diagnosticado de adenocarcinoma mesonefroide, es tratado mediante cirugía radical, a pesar de su mal pronóstico. CONCLUSIONES: Su diagnóstico diferencial entre estos tumores se debería hacerse con un adenocarcinoma primario o metastásico y un adenoma nefrogénico. Resaltar la controversia existente en la literatura en relación a la evolución maligna del adenoma nefrogénico como etiología del infrecuente adenocarcinoma mesonefroide. Así, en nuestro caso, el hallazgo previo de un adenoma nefrogénico apoya dicha teoría (AU)

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